abstract：:DBI/ACBP (diazepam binding protein, acyl-CoA binding protein) participates in the regulation of fatty acid metabolism when it is localized within cells, whereas outside of cells it acts as a diazepam-binding protein. Recent results indicate that many different mammalian cell types release DBI/ACBP upon in vitro or in ...

journal_title：Autophagy

authors： Bravo-San Pedro JM,Sica V,Martins I,Anagnostopoulos G,Maiuri C,Kroemer G

更新日期：2019-11-01 00:00:00

abstract：:There is overwhelming evidence for an association between impaired mitochondrial function and metabolic syndrome. Mitophagy, a process that selectively removes damaged mitochondria via a specialized form of autophagy, is essential for mitochondrial quality control (mitochondrial QC) and metabolic homeostasis. We thus ...

journal_title：Autophagy

authors： Wu H,Wang Y,Li W,Chen H,Du L,Liu D,Wang X,Xu T,Liu L,Chen Q

更新日期：2019-11-01 00:00:00

abstract：:Although alterations of the macroautophagy/autophagy-lysosome pathway have been observed in cancer for many years, the mechanisms underlying these changes and the importance of autophagic and lysosomal reprogramming by cancer have yet to be well identified. Our recent study demonstrates that oncogenic BRAF signaling p...

journal_title：Autophagy

authors： Li S,Song Y,Quach C,Nemecio D,Liang C

更新日期：2019-10-01 00:00:00

abstract：:A wide variety of genetic, pharmacological and nutrient manipulations that extend lifespan in model organisms do so in a manner dependent upon increased autophagic flux. However, our recent findings suggest that when mitochondrial membrane integrity is compromised, macroautophagy/autophagy can be detrimental. In C. el...

journal_title：Autophagy

authors： Zhou B,Soukas AA

更新日期：2019-10-01 00:00:00

abstract：:Photoreceptor degeneration and damages often lead to blindness, and the underlying molecular mechanisms are largely unknown. There is also a lot of missing information for establishing the role of macroautophagy/autophagy in the retinopathy. We recently generated knockout mouse lines of the essential gene Tubgcp4 (tub...

journal_title：Autophagy

authors： Xu X,Shang D,Cheng H,Klionsky DJ,Zhou R

更新日期：2019-10-01 00:00:00

abstract：:The NIH-funded center for autophagy research named Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence, located at the University of New Mexico Health Science Center is now completing its second year as a working center with a mission to promote autophagy research locally, nationally...

journal_title：Autophagy

authors： Deretic V,Prossnitz E,Burge M,Campen MJ,Cannon J,Liu KJ,Liu M,Hall P,Sklar LA,Allers L,Mariscal L,Garcia SA,Weaver J,Baehrecke EH,Behrends C,Cecconi F,Codogno P,Chen GC,Elazar Z,Eskelinen EL,Fourie B,Gozuacik D

更新日期：2019-10-01 00:00:00

abstract：:Based on my reading, and on my own experience, I have come to realize that people learn in different ways, and this can include the use of different media. This is one reason I have worked with various artists to portray the topic of autophagy through paintings, music and dance. Indeed, comments from members of the au...

journal_title：Autophagy

authors： Klionsky DJ

更新日期：2019-09-01 00:00:00

abstract：:Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes. Initiation of macroautophagy/autophagy is mediated by the ULK1 (unc-51 like autophagy activating kinase 1) protein kinase complex and the autophagy-specific class III phosphatidylinositol 3-kinase compl...

journal_title：Autophagy

authors： Birgisdottir ÅB,Mouilleron S,Bhujabal Z,Wirth M,Sjøttem E,Evjen G,Zhang W,Lee R,O'Reilly N,Tooze SA,Lamark T,Johansen T

更新日期：2019-08-01 00:00:00

abstract：:Numerous studies have reported that inhibition of MTOR (mechanistic target of rapamycin kinase) clearly reduces Alzheimer disease neuropathological hallmarks in mouse models. This has resulted in calls for the use of the MTOR inhibitor rapamycin for the treatment of dementia in humans. Unfortunately, intervention with...

journal_title：Autophagy

authors： Carosi JM,Sargeant TJ

更新日期：2019-08-01 00:00:00

abstract：:Macroautophagy/autophagy mediates the degradation of ubiquitinated aggregated proteins within lysosomes in a process known as aggrephagy. The cargo receptor SQSTM1/p62 condenses aggregated proteins into larger structures and links them to the nascent autophagosomal membrane (phagophore). How the condensation reaction ...

journal_title：Autophagy

authors： Turco E,Witt M,Abert C,Bock-Bierbaum T,Su MY,Trapannone R,Sztacho M,Danieli A,Shi X,Zaffagnini G,Gamper A,Schuschnig M,Fracchiolla D,Bernklau D,Romanov J,Hartl M,Hurley JH,Daumke O,Martens S

更新日期：2019-08-01 00:00:00

abstract：:Understanding of the mechanism for myeloid differentiation provides important insights into the hematopoietic developmental processes. By using an ESC-derived myeloid progenitor cell model, we found that CSF2/GM-CSF triggered macrophage differentiation and activation of the MTOR signaling pathway. Activation or inhibi...

journal_title：Autophagy

authors： Zhang M,Liu F,Zhou P,Wang Q,Xu C,Li Y,Bian L,Liu Y,Zhou J,Wang F,Yao Y,Fang Y,Li D

更新日期：2019-07-01 00:00:00

abstract：:Mutations in the ER-associated VAPB/ALS8 protein cause amyotrophic lateral sclerosis and spinal muscular atrophy. Previous studies have argued that ER stress may underlie the demise of neurons. We find that loss of VAP proteins (VAPs) leads to an accumulation of aberrant lysosomes and impairs lysosomal degradation. VA...

journal_title：Autophagy

authors： Mao D,Lin G,Tepe B,Zuo Z,Tan KL,Senturk M,Zhang S,Arenkiel BR,Sardiello M,Bellen HJ

更新日期：2019-07-01 00:00:00

abstract：:Macroautophagy/autophagy dysfunction is associated with many neurodegenerative diseases. TFEB (transcription factor EB), an important molecule that regulates lysosomal and autophagy function, is regarded as a potential target for treating some neurodegenerative diseases. However, the relationship between autophagy dys...

journal_title：Autophagy

authors： Ye B,Wang Q,Hu H,Shen Y,Fan C,Chen P,Ma Y,Wu H,Xiang M

更新日期：2019-06-01 00:00:00

abstract：:HSPB1 (heat shock protein family B [small] member 1) is a ubiquitously expressed molecular chaperone. Most mutations in HSPB1 cause axonal Charcot-Marie-Tooth neuropathy and/or distal hereditary motor neuropathy. In this study we show that mutations in HSPB1 lead to impairment of macroautophagic/autophagic flux. In HS...

journal_title：Autophagy

authors： Haidar M,Asselbergh B,Adriaenssens E,De Winter V,Timmermans JP,Auer-Grumbach M,Juneja M,Timmerman V

更新日期：2019-06-01 00:00:00

abstract：:Innate immune defense against intracellular pathogens, like Salmonella, relies heavily on the autophagy machinery of the host. This response is studied intensively in epithelial cells, the target of Salmonella during gastrointestinal infections. However, little is known of the role that autophagy plays in macrophages,...

journal_title：Autophagy

authors： Masud S,Prajsnar TK,Torraca V,Lamers GEM,Benning M,Van Der Vaart M,Meijer AH

更新日期：2019-05-01 00:00:00

abstract：:Cutaneous inflammation from UV radiation exposure causes epidermal damage, cellular infiltration, and secretion of pro-inflammatory mediators that exacerbate tissue destruction. Recovery is mediated chiefly by anti-inflammatory M2 macrophages that suppress inflammation and augment epidermal regeneration. Vitamin D ena...

journal_title：Autophagy

authors： Das LM,Binko AM,Traylor ZP,Peng H,Lu KQ

更新日期：2019-05-01 00:00:00

abstract：:Actin plays indispensable roles in autophagosome biogenesis. Branched actin networks assembled within phagophore membranes are required for generating the autophagosome membrane shape and movement. The ARP2/3 complex and its regulators, such as JMY (junction mediating and regulatory protein, p53 cofactor), translocate...

journal_title：Autophagy

authors： Liu X,Klionsky DJ

更新日期：2019-03-01 00:00:00

abstract：:Microglia are innate immune cells in the central nervous system (CNS), that supplies neurons with key factors for executing autophagosomal/lysosomal functions. Macroautophagy/autophagy is a cellular catabolic process that maintains cell balance in response to stress-related stimulation. Abnormal autophagy occurs with ...

journal_title：Autophagy

authors： Li Y,Zhou D,Ren Y,Zhang Z,Guo X,Ma M,Xue Z,Lv J,Liu H,Xi Q,Jia L,Zhang L,Liu Y,Zhang Q,Yan J,Da Y,Gao F,Yue J,Yao Z,Zhang R

更新日期：2019-03-01 00:00:00

abstract：:Macroautophagy/autophagy is a conserved catabolic process that maintains cellular homeostasis under basal growth and stress conditions. In cancer, autophagy can either prevent or promote tumor growth, at early or advanced stages, respectively. We screened public databases to identify autophagy-related somatic mutation...

journal_title：Autophagy

authors： Nuta GC,Gilad Y,Gershoni M,Sznajderman A,Schlesinger T,Bialik S,Eisenstein M,Pietrokovski S,Kimchi A

更新日期：2019-03-01 00:00:00

abstract：:The European autophagy consortium Driving next-generation autophagy researchers towards translation (DRIVE) held its kick-off meeting in Groningen on the 14th and 15th of June 2018. This Marie Skłodowska-Curie Early Training Network was approved under the European Union's Horizon 2020 Research and Innovation Program a...

journal_title：Autophagy

authors： Kraft C,Boya P,Codogno P,Elazar Z,Eskelinen EL,Farrés J,Kirkin V,Jungbluth H,Martinez A,Pless O,Primard C,Proikas-Cezanne T,Simonsen A,Reggiori F

更新日期：2019-02-01 00:00:00

abstract：:Phagocytosis and macroautophagy/autophagy are 2 processes involved in lysosome-mediated clearance of extracellular and intracellular components, respectively. Recent studies have identified the recruitment of the autophagic protein LC3 during phagocytosis of apoptotic corpses in what is now called LC3-associated phago...

journal_title：Autophagy

authors： Jenzer C,Simionato E,Largeau C,Scarcelli V,Lefebvre C,Legouis R

更新日期：2019-02-01 00:00:00

abstract：:We describe a protocol for rapid and efficient enrichment of autophagosomes from various tissues of the GFP-LC3 mouse. In order to increase the number of autophagosomes, we block autophagy flux in the GFP-LC3 mouse tissue with a single intraperitoneal injection of leupeptin 4-5 h before tissue harvesting. We homogeniz...

journal_title：Autophagy

authors： Yao J,Qiu Y,Jia L,Zacks DN

更新日期：2019-02-01 00:00:00

abstract：:Macroautophagy/autophagy is emerging as an important process in adult muscle stem cells functions: it regulates metabolic reprogramming during activation from a quiescent state, maintains stemness and prevents senescence. We now show that autophagy is specifically required for neonatal myogenesis and muscle developmen...

journal_title：Autophagy

authors： Zecchini S,Giovarelli M,Perrotta C,Morisi F,Touvier T,Di Renzo I,Moscheni C,Bassi MT,Cervia D,Sandri M,Clementi E,De Palma C

更新日期：2019-01-01 00:00:00

abstract：:Mitochondrial quality control is an essential process required to maintain cellular homeostasis and functions. Mutations of PINK1 and PRKN/PARK2 contribute to the risk of Parkinson disease. Our recent findings indicate that depletion of Pink1 and Prkn promotes pancreatic tumorigenesis in KRAS-driven engineered mouse m...

journal_title：Autophagy

authors： Kang R,Xie Y,Zeh HJ,Klionsky DJ,Tang D

更新日期：2019-01-01 00:00:00

abstract：:Macroautophagy/autophagy is a fundamental intracellular degradation process with multiple roles in immunity, including direct elimination of intracellular microorganisms via 'xenophagy.' In this review, we summarize studies from the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans that highlig...

journal_title：Autophagy

authors： Kuo CJ,Hansen M,Troemel E

更新日期：2018-01-01 00:00:00

abstract：:Aged and damaged mitochondria can be selectively degraded by specific autophagic elimination, termed mitophagy. Defects in mitophagy have been increasingly linked to several diseases including neurodegenerative diseases, metabolic diseases and other aging-related diseases. However, the molecular mechanisms of mitophag...

journal_title：Autophagy

authors： Xu G,Li T,Chen J,Li C,Zhao H,Yao C,Dong H,Wen K,Wang K,Zhao J,Xia Q,Zhou T,Zhang H,Gao P,Li A,Pan X

更新日期：2018-01-01 00:00:00

abstract：:ULK1 (unc51-like autophagy activating kinase 1) is a serine/threonine kinase that plays a key role in regulating macroautophagy/autophagy induction in response to amino acid starvation. Despite the recent progress in understanding ULK1 functions, the molecular mechanism by which ULK1 regulates the induction of autopha...

journal_title：Autophagy

authors： Park JM,Seo M,Jung CH,Grunwald D,Stone M,Otto NM,Toso E,Ahn Y,Kyba M,Griffin TJ,Higgins L,Kim DH

更新日期：2018-01-01 00:00:00

abstract：:Macroautophagy/autophagy is a catabolic process that is essential for cellular homeostasis. How autophagosomal vesicle forms in a spatio-temporally regulated manner remains elusive. Our recent study revealed that small GTPase, RAB37 (RAB37, member RAS oncogene family), functions as a key organizer of autophagosomal me...

journal_title：Autophagy

authors： Song Y,Shang D,Cheng H,Zhou R

更新日期：2018-01-01 00:00:00

abstract：:Ferroptosis is a form of regulated cell death caused by iron accumulation and oxidative injury. BECN1 is a key regulator of macroautophagy/autophagy, a catabolic process of degradation induced by starvation or other stressors. Our recent findings reveal a novel alternative mechanism by which BECN1 can promote ferropto...

journal_title：Autophagy

authors： Kang R,Zhu S,Zeh HJ,Klionsky DJ,Tang D

更新日期：2018-01-01 00:00:00

abstract：:Tumor-associated inflammation is predictive of poor prognosis and drives a variety of tumorigenic phenotypes, including tumor proliferation and survival, angiogenesis, invasiveness, and metastasis. Here, we review mammalian data addressing the interaction of macroautophagy/autophagy with key signaling cascades associa...

journal_title：Autophagy

authors： Monkkonen T,Debnath J

更新日期：2018-01-01 00:00:00

abstract：:In yeast, Tom22, the central component of the TOMM (translocase of outer mitochondrial membrane) receptor complex, is responsible for the recognition and translocation of synthesized mitochondrial precursor proteins, and its protein kinase CK2-dependent phosphorylation is mandatory for TOMM complex biogenesis and prop...

journal_title：Autophagy

authors： Kravic B,Harbauer AB,Romanello V,Simeone L,Vögtle FN,Kaiser T,Straubinger M,Huraskin D,Böttcher M,Cerqua C,Martin ED,Poveda-Huertes D,Buttgereit A,Rabalski AJ,Heuss D,Rudolf R,Friedrich O,Litchfield D,Marber M,Salvi

更新日期：2018-01-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is a chronic autoimmune inflammatory disease with severe inflammatory symptoms in the axial skeleton. The cause of ankylosing spondylitis is unknown. TNFAIP3, also named A20, uses ubiquitin-related functions to regulate immune activation, deficiency of which is highly related to autoimmune ...

journal_title：Autophagy

authors： Zhai Y,Lin P,Feng Z,Lu H,Han Q,Chen J,Zhang Y,He Q,Nan G,Luo X,Wang B,Feng F,Liu F,Chen Z,Zhu P

更新日期：2018-01-01 00:00:00

abstract：:The relationship between macroautophagy/autophagy and miRNA in regulating cancer cell motility is not clearly delineated. Here, we found that induction of BECN1-dependent or -independent autophagy decreased ubiquitin-binding proteins SQSTM1/p62 and CALCOCO2/NDP52. Downregulation of SQSTM1 (but not CALCOCO2) led to a d...

journal_title：Autophagy

authors： Liao CC,Ho MY,Liang SM,Liang CM

更新日期：2018-01-01 00:00:00

abstract：:The initiation of macroautophagy/autophagy is tightly regulated by the upstream ULK1 kinase complex, which affects many downstream factors including the PtdIns3K complex. The phosphorylation of the right position at the right time on downstream molecules is governed by proper complex formation. One component of the UL...

journal_title：Autophagy

authors： Kim BW,Jin Y,Kim J,Kim JH,Jung J,Kang S,Kim IY,Kim J,Cheong H,Song HK

更新日期：2018-01-01 00:00:00

abstract：:Post-translational modifications of autophagy-related (ATG) genes are necessary to modulate their functions. However, ATG protein methylation and its physiological role have not yet been elucidated. The methylation of non-histone proteins by SETD7, a SET domain-containing lysine methyltransferase, is a novel regulator...

journal_title：Autophagy

authors： Song H,Feng X,Zhang M,Jin X,Xu X,Wang L,Ding X,Luo Y,Lin F,Wu Q,Liang G,Yu T,Liu Q,Zhang Z

更新日期：2018-01-01 00:00:00

abstract：:Target of rapamycin complex 1 (TORC1) is an evolutionarily conserved protein kinase complex, whose activation in response to nutrients suppresses autophagy. In mammalian cells, amino-acid stimuli induce lysosomal translocation and activation of MTORC1 through the RRAG GTPase heterodimer, which is tethered to the surfa...

journal_title：Autophagy

authors： Fukuda T,Shiozaki K

更新日期：2018-01-01 00:00:00

abstract：:The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) and the enzyme that produces it, SPHK1 (sphingosine kinase 1), regulate many processes important for the etiology of cancer. It has been suggested that SPHK1 levels are regulated by the tumor suppressor protein TP53, a key regulator of cell cycle arre...

journal_title：Autophagy

authors： Lima S,Takabe K,Newton J,Saurabh K,Young MM,Leopoldino AM,Hait NC,Roberts JL,Wang HG,Dent P,Milstien S,Booth L,Spiegel S

更新日期：2018-01-01 00:00:00

abstract：:In 2013, Dr. Lora Hooper and colleagues described the induction of antibacterial macroautophagy/autophagy in intestinal epithelial cells as a cytoprotective host defense mechanism against invading Salmonella enterica serovar Typhimurium (S. Typhimurium). Canonical autophagy functions in a primarily degradative capacit...

journal_title：Autophagy

authors： Delorme-Axford E,Klionsky DJ

更新日期：2018-01-01 00:00:00

abstract：:Macroautophagy is induced under various stresses to remove cytotoxic materials, including misfolded proteins and their aggregates. These protein cargoes are collected by specific autophagic receptors such as SQSTM1/p62 (sequestosome 1) and delivered to phagophores for lysosomal degradation. To date, little is known ab...

journal_title：Autophagy

authors： Lee DH,Kim D,Kim ST,Jeong S,Kim JL,Shim SM,Heo AJ,Song X,Guo ZS,Bartlett DL,Oh SC,Lee J,Saito Y,Kim BY,Kwon YT,Lee YJ

更新日期：2018-01-01 00:00:00

abstract：:Macroautophagy/autophagy is the main intracellular catabolic pathway in neurons that eliminates misfolded proteins, aggregates and damaged organelles associated with ageing and neurodegeneration. Autophagy is regulated by both MTOR-dependent and -independent pathways. There is increasing evidence that autophagy is com...

journal_title：Autophagy

authors： Perera ND,Sheean RK,Lau CL,Shin YS,Beart PM,Horne MK,Turner BJ

更新日期：2018-01-01 00:00:00